LinDing Group


Welcome to Deform-nu

    Chromatin structure and functions are regulated by the positioning pattern of nucleosomes, which are fundamentally basic unit of eukaryotic chromatin. Various critical DNA-related activities like DNA replication, recombination, and transcription are subjected to nucleosome-mediated regulation. It is therefore important to identify nucleosome positions across the genome. We previously developed a deformation-energy model for predicting nucleosome positioning and verified its performance. Here, we developed a web-server for the model, which allows users to estimate several indices related to nucleosome positioning, such as nucleosome dyad position, nucleosome occupancy, and nucleosome free energy. The model and its results are easily interpretable. We provided examples to show the application and performance of the model. The success of the model supports that nucleosome positioning depends strongly on DNA physical properties such as deformation energy.