2'-O-methylation is catalyzed by the 2'-O-methylationtransferase, in which a methylation group is added to the 2' hydroxyl group of the ribose moiety of a nucleotide. iRNA-2OM is a system for identifying whether a RNA sequence contains the 2'-O-methylation site based on machine learning method. In the process of training model, nucleotide chemical properties were considered to build feature sets. The mRMR was used to determine the optimal number of feature, thus to achieve the optimal training model. 5-fold show that the proposed method can identifying the 2'-O-methylation site with an overall accuracy of 97.95%, We hope the webserver could provide convenience for wet-experimental scholars.
