O35244
UniProt ID : O35244
NCBI Taxonomy : 10116
Protein names : Peroxiredoxin-6
Organism : Rattus norvegicus
Taxonomy : Eukaryota
Subcellular locations :Cytoplasm;Lysosome;Cytoplasmic vesicle;
Length : 224
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0005737Cellular ComponentcytoplasmISS
GO:0016023Cellular Componentcytoplasmic membrane-bounded vesicleIEA
GO:0005764Cellular ComponentlysosomeIEA
GO:0004602Molecullar Functionglutathione peroxidase activityIDA
GO:0051920Molecullar Functionperoxiredoxin activityIEA
GO:0004623Molecullar Functionphospholipase A2 activityIEA
GO:0042744Biological Processhydrogen peroxide catabolic processIDA
GO:0009395Biological Processphospholipid catabolic processIEA
Catalytic activity :2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
SWISS-MODEL Repository :O35244
Sequences : MPGGLLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPIIDDKDRDLAILLGMLDPAEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPVDWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRYTPQP
Function :Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.