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O22287

UniProt ID :

O22287

NCBI Taxonomy :

3702

Protein names :

Mannose-1-phosphate guanylyltransferase 1

Organism :

Arabidopsis thaliana

Taxonomy :

Eukaryota

Length :

361

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IDA
GO:0005634	Cellular Component	nucleus	IDA
GO:0005525	Molecullar Function	GTP binding	IEA
GO:0004475	Molecullar Function	mannose-1-phosphate guanylyltransferase activity	IMP
GO:0030244	Biological Process	cellulose biosynthetic process	IMP
GO:0042742	Biological Process	defense response to bacterium	IMP
GO:0009298	Biological Process	GDP-mannose biosynthetic process	IEA
GO:0019853	Biological Process	L-ascorbic acid biosynthetic process	IMP
GO:0060359	Biological Process	response to ammonium ion	IMP
GO:0009408	Biological Process	response to heat	IMP
GO:0009753	Biological Process	response to jasmonic acid stimulus	IEP
GO:0010193	Biological Process	response to ozone	IEP
GO:0009651	Biological Process	response to salt stress	IMP

Catalytic activity :

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

SWISS-MODEL Repository :

O22287

Sequences :

MKALILVGGFGTRLRPLTLSFPKPLVDFANKPMILHQIEALKAVGVDEVVLAINYQPEVMLNFLKDFETKLEIKITCSQETEPLGTAGPLALARDKLLDGSGEPFFVLNSDVISEYPLKEMLEFHKSHGGEASIMVTKVDEPSKYGVVVMEESTGRVEKFVEKPKLYVGNKINAGIYLLNPSVLDKIELRPTSIEKETFPKIAAAQGLYAMVLPGFWMDIGQPRDYITGLRLYLDSLRKKSPAKLTSGPHIVGNVLVDETATIGEGCLIGPDVAIGPGCIVESGVRLSRCTVMRGVRIKKHACISSSIIGWHSTVGQWARIENMTILGEDVHVSDEIYSNGGVVLPHKEIKSNILKPEIVM

Function :

Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate.