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O08807

UniProt ID :

O08807

NCBI Taxonomy :

10090

Protein names :

Peroxiredoxin-4

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Secreted;

Length :

274

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IEA
GO:0005739	Cellular Component	mitochondrion	IDA
GO:0004601	Molecullar Function	peroxidase activity	IEA
GO:0051920	Molecullar Function	peroxiredoxin activity	IEA
GO:0008584	Biological Process	male gonad development	IMP
GO:2000255	Biological Process	negative regulation of male germ cell proliferation	IMP
GO:0055114	Biological Process	oxidation-reduction process	IMP
GO:0072593	Biological Process	reactive oxygen species metabolic process	IDA
GO:0007283	Biological Process	spermatogenesis	IMP

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

O08807

Sequences :

MEARSKLLDGTTASRRWTRKLVLLLPPLLLFLLRTESLQGLESDERFRTRENECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN

Function :

Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.