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Q9Z0V6

UniProt ID :

Q9Z0V6

NCBI Taxonomy :

10116

Protein names :

Thioredoxin-dependent peroxide reductase, mitochondrial

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Mitochondrion;

Length :

257

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005739	Cellular Component	mitochondrion	IDA
GO:0004601	Molecullar Function	peroxidase activity	IEA
GO:0051920	Molecullar Function	peroxiredoxin activity	IEA
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IMP

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

Q9Z0V6

Sequences :

MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDMLWSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEEPLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ

Function :

Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity).