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Q9URV9

UniProt ID :

Q9URV9

NCBI Taxonomy :

284812

Protein names :

Sulfiredoxin

Organism :

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

124

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IDA
GO:0005634	Cellular Component	nucleus	IDA
GO:0005524	Molecullar Function	ATP binding	IEA
GO:0003677	Molecullar Function	DNA binding	IEA
GO:0032542	Molecullar Function	sulfiredoxin activity	IDA
GO:0034613	Biological Process	cellular protein localization	IMP
GO:0070301	Biological Process	cellular response to hydrogen peroxide	IMP

Catalytic activity :

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

Sequences :

MTSIHTGSNNNIVELDMSELIRPIPPVLDMNKVNSMMETMTGKTPPASCGLTSEDLEAGELPPVDVLTFKKSGKPYYFAFGGCHRLRAHDEAGRKKVRCKLVNCSPNTLRLYLGASANKFLDSD

Function :

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.