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Q9UI32

UniProt ID :

Q9UI32

NCBI Taxonomy :

9606

Protein names :

Glutaminase liver isoform, mitochondrial

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Mitochondrion;

Length :

602

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005759	Cellular Component	mitochondrial matrix	TAS
GO:0004359	Molecullar Function	glutaminase activity	TAS
GO:0008652	Biological Process	cellular amino acid biosynthetic process	TAS
GO:0034641	Biological Process	cellular nitrogen compound metabolic process	TAS
GO:0014047	Biological Process	glutamate secretion	TAS
GO:0006541	Biological Process	glutamine metabolic process	IEA
GO:0007269	Biological Process	neurotransmitter secretion	TAS
GO:0072593	Biological Process	reactive oxygen species metabolic process	IMP
GO:0042981	Biological Process	regulation of apoptotic process	IMP

Catalytic activity :

L-glutamine + H₂O = L-glutamate + NH(3).

SWISS-MODEL Repository :

Q9UI32

Sequences :

MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV

Function :

Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.