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Q9R1P4

UniProt ID :

Q9R1P4

NCBI Taxonomy :

10090

Protein names :

Proteasome subunit alpha type-1

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

263

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	TAS
GO:0005634	Cellular Component	nucleus	IEA
GO:0005839	Cellular Component	proteasome core complex	IDA
GO:0019773	Cellular Component	proteasome core complex, alpha-subunit complex	IEA
GO:0001530	Molecullar Function	lipopolysaccharide binding	IDA
GO:0004298	Molecullar Function	threonine-type endopeptidase activity	IEA
GO:0002862	Biological Process	negative regulation of inflammatory response to antigenic stimulus	IMP
GO:0006511	Biological Process	ubiquitin-dependent protein catabolic process	IEA

Catalytic activity :

Cleavage of peptide bonds with very broad specificity.

SWISS-MODEL Repository :

Q9R1P4

Sequences :

MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH

Function :

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.