Q9R063
UniProt ID : Q9R063
NCBI Taxonomy : 10116
Protein names : Peroxiredoxin-5, mitochondrial
Organism : Rattus norvegicus
Taxonomy : Eukaryota
Subcellular locations :Mitochondrion;Cytoplasm;Peroxisome;
Length : 213
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0031410Cellular Componentcytoplasmic vesicleIEA
GO:0005829Cellular ComponentcytosolIEA
GO:0005739Cellular ComponentmitochondrionIDA
GO:0005634Cellular ComponentnucleusIEA
GO:0048471Cellular Componentperinuclear region of cytoplasmIEA
GO:0005782Cellular Componentperoxisomal matrixIEA
GO:0005777Cellular ComponentperoxisomeIDA
GO:0043027Molecullar Functioncysteine-type endopeptidase inhibitor activity involved in apoptotic processIEA
GO:0004601Molecullar Functionperoxidase activityIEA
GO:0072541Molecullar Functionperoxynitrite reductase activityIEA
GO:0001016Molecullar FunctionRNA polymerase III regulatory region DNA bindingIEA
GO:0042744Biological Processhydrogen peroxide catabolic processIEA
GO:0070995Biological ProcessNADPH oxidationIEA
GO:0043066Biological Processnegative regulation of apoptotic processIEA
GO:0051354Biological Processnegative regulation of oxidoreductase activityIEA
GO:0016480Biological Processnegative regulation of transcription from RNA polymerase III promoterIEA
GO:0032967Biological Processpositive regulation of collagen biosynthetic processIEA
GO:2001057Biological Processreactive nitrogen species metabolic processIEA
GO:0060785Biological Processregulation of apoptosis involved in tissue homeostasisIEA
Catalytic activity :2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
SWISS-MODEL Repository :Q9R063
Sequences : MVQLRFCVLGSIAGSVLRASATWTCVAGRAGRKGAGWECGGARSFSSAAVTMAPIKVGDTIPSVEVFEGEPGKKVNLAELFKDKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDAFVTAEWGRAHQAEGKVQLLADPTGAFGKETDLLLDDSLVSLFGNRRLKRFSMVIDKGVVKALNVEPDGTGLTCSLAPNILSQL
Function :Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (By similarity).