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O00522

UniProt ID :

O00522

NCBI Taxonomy :

9606

Protein names :

Krev interaction trapped protein 1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Cell membrane;Cell junction;

Length :

736

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005911	Cellular Component	cell-cell junction	IDA
GO:0005737	Cellular Component	cytoplasm	IEA
GO:0005874	Cellular Component	microtubule	IDA
GO:0005886	Cellular Component	plasma membrane	IDA
GO:0008017	Molecullar Function	microtubule binding	IDA
GO:0005546	Molecullar Function	phosphatidylinositol-4,5-bisphosphate binding	IDA
GO:0032403	Molecullar Function	protein complex binding	IDA
GO:0005083	Molecullar Function	small GTPase regulator activity	TAS
GO:0001525	Biological Process	angiogenesis	IEA
GO:0045454	Biological Process	cell redox homeostasis	IMP
GO:0016525	Biological Process	negative regulation of angiogenesis	IMP
GO:2000352	Biological Process	negative regulation of endothelial cell apoptotic process	IMP
GO:0010596	Biological Process	negative regulation of endothelial cell migration	IMP
GO:0001937	Biological Process	negative regulation of endothelial cell proliferation	IMP
GO:0032092	Biological Process	positive regulation of protein binding	IEA
GO:2000114	Biological Process	regulation of establishment of cell polarity	IMP
GO:0007264	Biological Process	small GTPase mediated signal transduction	TAS

SWISS-MODEL Repository :

O00522

Sequences :

MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYEILLHEVPIEGQKKKRKKVLLETKLQGNSEITQGILDYVVETTKPISPANQGIRGKRVVLMKKFPLDGEKMGREASLFIVPSVVKDNTKYTYTPGCPIFYCLQDIMRVCSESSTHFATLTARMLIALDKWLDERHAQSHFIPALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS

Function :

Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits EKR1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.