Q9H2X6
UniProt ID : Q9H2X6
NCBI Taxonomy : 9606
Protein names : Homeodomain-interacting protein kinase 2
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Nucleus;Cytoplasm;
Length : 1198
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0005813Cellular ComponentcentrosomeIDA
GO:0005737Cellular ComponentcytoplasmISS
GO:0016604Cellular Componentnuclear bodyIDA
GO:0031965Cellular Componentnuclear membraneIDA
GO:0016605Cellular ComponentPML bodyIEA
GO:0005524Molecullar FunctionATP bindingIEA
GO:0004674Molecullar Functionprotein serine/threonine kinase activityISS
GO:0001102Molecullar FunctionRNA polymerase II activating transcription factor bindingISS
GO:0001105Molecullar FunctionRNA polymerase II transcription coactivator activityIEA
GO:0003714Molecullar Functiontranscription corepressor activityIDA
GO:0046790Molecullar Functionvirion bindingIPI
GO:0007628Biological Processadult walking behaviorIEA
GO:0009952Biological Processanterior/posterior pattern specificationIEA
GO:0071456Biological Processcellular response to hypoxiaTAS
GO:0006978Biological ProcessDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDA
GO:0048596Biological Processembryonic camera-type eye morphogenesisIEA
GO:0060059Biological Processembryonic retina morphogenesis in camera-type eyeIEA
GO:0030218Biological Processerythrocyte differentiationISS
GO:0001654Biological Processeye developmentISS
GO:0042771Biological Processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorTAS
GO:0061072Biological Processiris morphogenesisIEA
GO:0060235Biological Processlens induction in camera-type eyeIEA
GO:0019048Biological Processmodulation by virus of host morphology or physiologyNAS
GO:0030514Biological Processnegative regulation of BMP signaling pathwayIMP
GO:0043524Biological Processnegative regulation of neuron apoptotic processIEA
GO:0000122Biological Processnegative regulation of transcription from RNA polymerase II promoterIEA
GO:0030182Biological Processneuron differentiationIEA
GO:0018105Biological Processpeptidyl-serine phosphorylationISS
GO:0018107Biological Processpeptidyl-threonine phosphorylationISS
GO:0030578Biological ProcessPML body organizationTAS
GO:0045766Biological Processpositive regulation of angiogenesisIDA
GO:0008284Biological Processpositive regulation of cell proliferationIEA
GO:0043388Biological Processpositive regulation of DNA bindingIEA
GO:0046330Biological Processpositive regulation of JNK cascadeIMP
GO:0032092Biological Processpositive regulation of protein bindingISS
GO:0051091Biological Processpositive regulation of sequence-specific DNA binding transcription factor activityISS
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoterISS
GO:0030511Biological Processpositive regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0051726Biological Processregulation of cell cycleTAS
GO:0010842Biological Processretina layer formationIEA
GO:0060395Biological ProcessSMAD protein signal transductionIDA
GO:0007224Biological Processsmoothened signaling pathwayIEA
GO:0007179Biological Processtransforming growth factor beta receptor signaling pathwayIEA
GO:0050882Biological Processvoluntary musculoskeletal movementIEA
Catalytic activity :ATP + a protein = ADP + a phosphoprotein.
SWISS-MODEL Repository :Q9H2X6
Sequences : MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Function :Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.