show

Q9D975

UniProt ID :

Q9D975

NCBI Taxonomy :

10090

Protein names :

Sulfiredoxin-1

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;

Length :

136

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	ISS
GO:0005524	Molecullar Function	ATP binding	IEA
GO:0003677	Molecullar Function	DNA binding	IEA
GO:0016667	Molecullar Function	oxidoreductase activity, acting on a sulfur group of donors	IDA
GO:0032542	Molecullar Function	sulfiredoxin activity	IEA
GO:0006979	Biological Process	response to oxidative stress	IDA

Catalytic activity :

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.Magnesium (By similarity).

SWISS-MODEL Repository :

Q9D975

Sequences :

MGLRAGGALRRAGAGPGAPEGQGPGGAQGGSIHSGCIATVHNVPIAVLIRPLPSVLDPAKVQSLVDTILADPDSVPPIDVLWIKGAQGGDYYYSFGGCHRYAAYQQLQRETIPAKLVRSTLSDLRMYLGASTPDLQ

Function :

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.