Q9BYN0
UniProt ID : Q9BYN0
NCBI Taxonomy : 9606
Protein names : Sulfiredoxin-1
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Cytoplasm;
Length : 137
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0005829Cellular ComponentcytosolIDA
GO:0005524Molecullar FunctionATP bindingIEA
GO:0003677Molecullar FunctionDNA bindingIEA
GO:0016667Molecullar Functionoxidoreductase activity, acting on a sulfur group of donorsIDA
GO:0032542Molecullar Functionsulfiredoxin activityIEA
GO:0006979Biological Processresponse to oxidative stressIDA
Catalytic activity :Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.Magnesium (By similarity).
SWISS-MODEL Repository :Q9BYN0
Sequences : MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ
Function :Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.