Q9BQE4
UniProt ID : Q9BQE4
NCBI Taxonomy : 9606
Protein names : Selenoprotein S
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Endoplasmic reticulum membrane;Cytoplasm;
Length : 189
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0005881Cellular Componentcytoplasmic microtubuleIDA
GO:0030176Cellular Componentintegral to endoplasmic reticulum membraneIDA
GO:0034362Cellular Componentlow-density lipoprotein particleIDA
GO:0005886Cellular Componentplasma membraneTAS
GO:0034361Cellular Componentvery-low-density lipoprotein particleIDA
GO:0016209Molecullar Functionantioxidant activityIDA
GO:0004872Molecullar Functionreceptor activityNAS
GO:0008430Molecullar Functionselenium bindingIEA
GO:0045454Biological Processcell redox homeostasisIDA
GO:0032869Biological Processcellular response to insulin stimulusTAS
GO:0071222Biological Processcellular response to lipopolysaccharideIMP
GO:0034599Biological Processcellular response to oxidative stressIMP
GO:0030968Biological Processendoplasmic reticulum unfolded protein responseIDA
GO:0006983Biological ProcessER overload responseIDA
GO:0030433Biological ProcessER-associated protein catabolic processIDA
GO:0002865Biological Processnegative regulation of acute inflammatory response to antigenic stimulusIMP
GO:0046325Biological Processnegative regulation of glucose importTAS
GO:0045719Biological Processnegative regulation of glycogen biosynthetic processTAS
GO:0032715Biological Processnegative regulation of interleukin-6 productionISS
GO:1902236Biological Processnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMP
GO:2000110Biological Processnegative regulation of macrophage apoptotic processIMP
GO:0051771Biological Processnegative regulation of nitric-oxide synthase biosynthetic processIMP
GO:0032720Biological Processnegative regulation of tumor necrosis factor productionISS
GO:0006111Biological Processregulation of gluconeogenesisTAS
GO:0080164Biological Processregulation of nitric oxide metabolic processIMP
GO:0009749Biological Processresponse to glucose stimulusIEP
GO:0051775Biological Processresponse to redox stateIDA
GO:0030970Biological Processretrograde protein transport, ER to cytosolIDA
SWISS-MODEL Repository :Q9BQE4
Sequences : MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQRQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDSMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGRRGPSSGGUG
Function :Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.