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Q99497

UniProt ID :

Q99497

NCBI Taxonomy :

9606

Protein names :

Protein DJ-1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;Mitochondrion;

Length :

189

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005739	Cellular Component	mitochondrion	IDA
GO:0005634	Cellular Component	nucleus	IDA
GO:0003729	Molecullar Function	mRNA binding	IDA
GO:0008233	Molecullar Function	peptidase activity	IDA
GO:0004601	Molecullar Function	peroxidase activity	ISS
GO:0051920	Molecullar Function	peroxiredoxin activity	IEA
GO:0042803	Molecullar Function	protein homodimerization activity	IDA
GO:0008344	Biological Process	adult locomotory behavior	IEA
GO:0006914	Biological Process	autophagy	IEA
GO:0008219	Biological Process	cell death	IEA
GO:0070301	Biological Process	cellular response to hydrogen peroxide	IDA
GO:0051583	Biological Process	dopamine uptake involved in synaptic transmission	IEA
GO:0042743	Biological Process	hydrogen peroxide metabolic process	IEA
GO:0006954	Biological Process	inflammatory response	IEA
GO:0051899	Biological Process	membrane depolarization	IEA
GO:0060081	Biological Process	membrane hyperpolarization	IEA
GO:0007005	Biological Process	mitochondrion organization	ISS
GO:2001237	Biological Process	negative regulation of extrinsic apoptotic signaling pathway	IMP
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IDA
GO:0032091	Biological Process	negative regulation of protein binding	IDA
GO:2000277	Biological Process	positive regulation of oxidative phosphorylation uncoupler activity	IEA
GO:0050821	Biological Process	protein stabilization	IMP
GO:0006508	Biological Process	proteolysis	IEA
GO:0060765	Biological Process	regulation of androgen receptor signaling pathway	IDA
GO:0050727	Biological Process	regulation of inflammatory response	ISS
GO:0007338	Biological Process	single fertilization	IEA

SWISS-MODEL Repository :

Q99497

Sequences :

MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD

Function :

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.