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Q63716

UniProt ID :

Q63716

NCBI Taxonomy :

10116

Protein names :

Peroxiredoxin-1

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Melanosome;

Length :

199

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IDA
GO:0042470	Cellular Component	melanosome	IEA
GO:0005759	Cellular Component	mitochondrial matrix	IDA
GO:0005719	Cellular Component	nuclear euchromatin	IDA
GO:0005730	Cellular Component	nucleolus	IDA
GO:0005782	Cellular Component	peroxisomal matrix	IDA
GO:0020037	Molecullar Function	heme binding	IPI
GO:0051920	Molecullar Function	peroxiredoxin activity	IDA
GO:0042803	Molecullar Function	protein homodimerization activity	IDA
GO:0008379	Molecullar Function	thioredoxin peroxidase activity	IEA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	IEA
GO:0006979	Biological Process	response to oxidative stress	IDA

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

Q63716

Sequences :

MSSGNAKIGHPAPSFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEILRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK

Function :

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).