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Q61985

UniProt ID :

Q61985

NCBI Taxonomy :

10090

Protein names :

Nuclear factor erythroid 2-related factor 1

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Endoplasmic reticulum membrane;Nucleus;Cytoplasm;Nucleus;

Length :

741

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005789	Cellular Component	endoplasmic reticulum membrane	IEA
GO:0016021	Cellular Component	integral to membrane	IEA
GO:0005634	Cellular Component	nucleus	IDA
GO:0001190	Molecullar Function	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IDA
GO:0043565	Molecullar Function	sequence-specific DNA binding	IEA
GO:0003700	Molecullar Function	sequence-specific DNA binding transcription factor activity	IEA
GO:0030218	Biological Process	erythrocyte differentiation	IMP

SWISS-MODEL Repository :

Q61985

Sequences :

MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNSGLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVDKELQDGREREDTWSGEGAEALARDLLVDGETGESFPAQFPADVSSIPEAVPSESESPALQNSLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYNAPPGDPLSTNYSLAPNTPINQNVSLHQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPSQLNGTANDTSGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTLKKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDEHGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK

Function :

Isoform 3 interacts with the extended kappa 3 site of the TNF alpha promoter after Fc gamma RIII stimulation and participates in the induction of this cytokine. According to PubMed:9580677, isoform 1 is either inactive or represses the transcriptional activation. Isoform 2 activates the expression of antioxidant response element (ARE) containing reporters and genes in cells, and may play a role in oxidative stress response. According to PubMed:23144760, isoform 1 also activates ARE-driven genes.