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Q60928

UniProt ID :

Q60928

NCBI Taxonomy :

10090

Protein names :

Gamma-glutamyltranspeptidase 1

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Membrane;

Length :

568

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005887	Cellular Component	integral to plasma membrane	TAS
GO:0003840	Molecullar Function	gamma-glutamyltransferase activity	ISS
GO:0036374	Molecullar Function	glutathione hydrolase activity	IEA
GO:0071260	Biological Process	cellular response to mechanical stimulus	TAS
GO:0019344	Biological Process	cysteine biosynthetic process	IMP
GO:0006750	Biological Process	glutathione biosynthetic process	IMP
GO:0060427	Biological Process	lung connective tissue development	TAS
GO:0002682	Biological Process	regulation of immune system process	IMP
GO:0050727	Biological Process	regulation of inflammatory response	IMP
GO:0007283	Biological Process	spermatogenesis	IMP

Catalytic activity :

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.Glutathione + H₂O = L-cysteinylglycine + L-glutamate.Leukotriene C(4) + H₂O = leukotriene D(4) + L-glutamate.

SWISS-MODEL Repository :

Q60928

Sequences :

MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVATDAKRCSEIGRDILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEVINAREVAPRLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGAKAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSPANFIKPGKQPLSSMCPSIILDKDGQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPAGY

Function :

Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Indirectly regulates multiple aspects of skeletal biology.