| Q5NUA6 |
| UniProt ID : |
Q5NUA6 |
| NCBI Taxonomy : |
9913 |
| Protein names : |
Nuclear factor erythroid 2-related factor 2 |
| Organism : |
Bos taurus |
| Taxonomy : |
Eukaryota |
| Subcellular locations : | Cytoplasm;Nucleus; |
| Length : |
607 |
| Gene Ontology : | | GO ID | Ontology | Definition | Evidence | | GO:0005829 | Cellular Component | cytosol | IEA | | GO:0005634 | Cellular Component | nucleus | IEA | | GO:0043565 | Molecullar Function | sequence-specific DNA binding | IEA | | GO:0003700 | Molecullar Function | sequence-specific DNA binding transcription factor activity | IEA | | GO:0043161 | Biological Process | proteasomal ubiquitin-dependent protein catabolic process | ISS | | GO:0010499 | Biological Process | proteasomal ubiquitin-independent protein catabolic process | ISS | | GO:0016567 | Biological Process | protein ubiquitination | ISS | | GO:0006351 | Biological Process | transcription, DNA-dependent | IEA | |
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| Sequences : |
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKKPDTKKN |
| Function : | Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). |