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Q5E947

UniProt ID :

Q5E947

NCBI Taxonomy :

9913

Protein names :

Peroxiredoxin-1

Organism :

Bos taurus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Melanosome;

Length :

199

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0042470	Cellular Component	melanosome	IEA
GO:0005739	Cellular Component	mitochondrion	IEA
GO:0005634	Cellular Component	nucleus	IEA
GO:0008379	Molecullar Function	thioredoxin peroxidase activity	IEA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	IEA
GO:0042345	Biological Process	regulation of NF-kappaB import into nucleus	ISS
GO:0006979	Biological Process	response to oxidative stress	ISS

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

Q5E947

Sequences :

MSSGNAKIGHRAPQFKATAVMPDGQFKDISLADYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLISDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK

Function :

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).