| B3EWR3 |
| UniProt ID : |
B3EWR3 |
| NCBI Taxonomy : |
35670 |
| Protein names : |
Cytotoxin NN-32 |
| Organism : |
Naja naja |
| Taxonomy : |
Eukaryota |
| Subcellular locations : | Secreted; |
| Length : |
10 |
| Gene Ontology : | | GO ID | Ontology | Definition | Evidence | | GO:0005576 | Cellular Component | extracellular region | IEA | | GO:0019835 | Biological Process | cytolysis | IEA | |
|
| Sequences : |
LKCNKLVPLF |
| Function : | Shows cytotoxic activity against Ehrlich ascites carcinoma (EAC) model in mice. Also shows effect on apoptotic features such as nuclear fragmentation, caspase activity, pro- and anti-apoptotic protein levels on treated EAC cells. Increased levels of antioxidant enzymes and cytokine levels observed in toxin-treated EAC mice. Cardiotoxic towards guinea pig auricle. Has no cytotoxicity towards macrophages in vivo in EAC bearing mice or in vitro in normal human lymphocytes. |