Q2TBU0
UniProt ID : Q2TBU0
NCBI Taxonomy : 9913
Protein names : Haptoglobin
Organism : Bos taurus
Taxonomy : Eukaryota
Subcellular locations :Secreted;
Length : 401
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0005615Cellular Componentextracellular spaceIEA
GO:0016209Molecullar Functionantioxidant activityIEA
GO:0003824Molecullar Functioncatalytic activityIEA
GO:0006953Biological Processacute-phase responseIEA
GO:0042742Biological Processdefense response to bacteriumIEA
GO:0008152Biological Processmetabolic processIEA
Sequences : MSALQAVVTLLLCGQLLAVETGSEATADSCPKAPEIANSHVEYSVRYQCDKYYKLHAGNGVYTFNNKQWINKDIGQQLPECEEDDSCPEPPKIENGYVEYLVRYQCKPYYTLRTCGDGVYTFNSKKQWINKNIGQKLPECEAVCGKPKHPVDQVQRIIGGSLDAKGSFPWQAKMVSQHNLISGATLINERWLLTTAKNLYLGHSSDKKAKDITPTLRLYVGKNQLVEVEKVVLHPDHSKVDIGLIKLRQKVPVNDKVMPICLPSKDYVKVGRVGYVSGWGRNENFNFTEHLKYVMLPVADQDKCVKHYEGVDAPKNKTAKSPVGVQPILNENTFCVGLSKYQDDTCYGDAGSAFVVHDKEDDTWYAAGILSFDKSCAVAEYGVYVKVTSILDWVRKTIANN
Function :As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).