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Q2G282

UniProt ID :

Q2G282

NCBI Taxonomy :

93061

Protein names :

Peroxide-responsive repressor PerR

Organism :

Staphylococcus aureus (strain NCTC 8325)

Taxonomy :

Bacteria

Subcellular locations :

Cytoplasm;

Length :

148

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005737	Cellular Component	cytoplasm	IEA
GO:0003677	Molecullar Function	DNA binding	IEA
GO:0046872	Molecullar Function	metal ion binding	IEA
GO:0003700	Molecullar Function	sequence-specific DNA binding transcription factor activity	IEA
GO:0006351	Biological Process	transcription, DNA-dependent	IEA

SWISS-MODEL Repository :

Q2G282

Sequences :

MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Function :

Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection.