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A0QQJ4

UniProt ID :

A0QQJ4

NCBI Taxonomy :

246196

Protein names :

F420-dependent glucose-6-phosphate dehydrogenase

Organism :

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomy :

Bacteria

Length :

336

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0070967	Molecullar Function	coenzyme F420 binding	IDA
GO:0052749	Molecullar Function	glucose-6-phosphate dehydrogenase (coenzyme F420) activity	IEA
GO:0016614	Molecullar Function	oxidoreductase activity, acting on CH-OH group of donors	IDA
GO:0016705	Molecullar Function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0042803	Molecullar Function	protein homodimerization activity	IDA
GO:0005975	Biological Process	carbohydrate metabolic process	IEA

Catalytic activity :

D-glucose 6-phosphate + oxidized coenzyme F420 = D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420.

SWISS-MODEL Repository :

A0QQJ4

Sequences :

MAELKLGYKASAEQFAPRELVELAVLAESAGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKNLVLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYAGEWPEFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGASIYDVPEGGIPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYAEKLIPAVKEGAAAADRDADAIDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEKVGQYVKWGLNHLVFHAPGHDQRRFLELFKRDLEPRLRKLA

Function :

Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Can not use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6-phosphate or D-fructose-6-phosphate as substrate.