UniProt ID : A0QQJ4
NCBI Taxonomy : 246196
Protein names : F420-dependent glucose-6-phosphate dehydrogenase
Organism : Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomy : Bacteria
Length : 336
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0070967Molecullar Functioncoenzyme F420 bindingIDA
GO:0052749Molecullar Functionglucose-6-phosphate dehydrogenase (coenzyme F420) activityIEA
GO:0016614Molecullar Functionoxidoreductase activity, acting on CH-OH group of donorsIDA
GO:0016705Molecullar Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEA
GO:0042803Molecullar Functionprotein homodimerization activityIDA
GO:0005975Biological Processcarbohydrate metabolic processIEA
Catalytic activity :D-glucose 6-phosphate + oxidized coenzyme F420 = D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420.
SWISS-MODEL Repository :A0QQJ4
Function :Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Can not use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6-phosphate or D-fructose-6-phosphate as substrate.