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Q15165

UniProt ID :

Q15165

NCBI Taxonomy :

9606

Protein names :

Serum paraoxonase/arylesterase 2

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Membrane;

Length :

354

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	IEA
GO:0005764	Cellular Component	lysosome	IEA
GO:0005739	Cellular Component	mitochondrion	IEA
GO:0005634	Cellular Component	nucleus	IEA
GO:0005886	Cellular Component	plasma membrane	IDA
GO:0004064	Molecullar Function	arylesterase activity	TAS
GO:0042802	Molecullar Function	identical protein binding	IDA
GO:0046872	Molecullar Function	metal ion binding	IEA
GO:0019439	Biological Process	aromatic compound catabolic process	IDA
GO:0006979	Biological Process	response to oxidative stress	IEA

Catalytic activity :

A phenyl acetate + H₂O = a phenol + acetate.An N-acyl-L-homoserine lactone + H₂O = an N-acyl-L-homoserine.

SWISS-MODEL Repository :

Q15165

Sequences :

MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL

Function :

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.