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Q14145

UniProt ID :

Q14145

NCBI Taxonomy :

9606

Protein names :

Kelch-like ECH-associated protein 1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

624

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005813	Cellular Component	centrosome	IDA
GO:0031463	Cellular Component	Cul3-RING ubiquitin ligase complex	IDA
GO:0005737	Cellular Component	cytoplasm	IDA
GO:0005783	Cellular Component	endoplasmic reticulum	IEA
GO:0030496	Cellular Component	midbody	IDA
GO:0005634	Cellular Component	nucleus	IDA
GO:0071353	Biological Process	cellular response to interleukin-4	IEA
GO:0001701	Biological Process	in utero embryonic development	IEA
GO:0010499	Biological Process	proteasomal ubiquitin-independent protein catabolic process	IDA
GO:0016567	Biological Process	protein ubiquitination	IDA
GO:0045604	Biological Process	regulation of epidermal cell differentiation	IEA
GO:0006355	Biological Process	regulation of transcription, DNA-dependent	IEA
GO:0006351	Biological Process	transcription, DNA-dependent	IEA

SWISS-MODEL Repository :

Q14145

Sequences :

MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC

Function :

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.