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Q10252

UniProt ID :

Q10252

NCBI Taxonomy :

284812

Protein names :

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Organism :

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Taxonomy :

Eukaryota

Subcellular locations :

Mitochondrion inner membrane;

Length :

360

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0031305	Cellular Component	integral to mitochondrial inner membrane	IC
GO:0002083	Molecullar Function	4-hydroxybenzoate decaprenyltransferase activity	IEA
GO:0047293	Molecullar Function	4-hydroxybenzoate nonaprenyltransferase activity	IEA
GO:0008412	Molecullar Function	4-hydroxybenzoate octaprenyltransferase activity	IMP
GO:0016209	Molecullar Function	antioxidant activity	IMP
GO:0019646	Biological Process	aerobic electron transport chain	TAS
GO:0071276	Biological Process	cellular response to cadmium ion	IMP
GO:0071585	Biological Process	detoxification of cadmium ion	IMP
GO:0008299	Biological Process	isoprenoid biosynthetic process	IEA
GO:0006119	Biological Process	oxidative phosphorylation	TAS
GO:0006744	Biological Process	ubiquinone biosynthetic process	IMP

Catalytic activity :

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.

Sequences :

MEMALLPQPSPARYFLRTPSWSAVAIFQAVKIKPLQLRTNSSNSVTPNLISPSKKSWKDLFSKRWQYYAEISRAGSPTGTYLLYSPCTWSILMAAYAYDSSLVNVTKMLALFGVGSFLMRSAGCVINDLWDRELDAKVERSKSRPLASGKLSVRQAISLLSVQLTASLGILLQLNPYTIKLGVASLVPVCIYPAMKRITYYPQVVLGLTFGYGAVMGWPALAGEACMNWSVVAPLYLSTISWIVLYDTIYAHQDKRDDVKANIYSTALRFGDNTKPVLCGLAALQIATLATAGIMNGQGPVFYTLGVAGAAYRLSSMIYKVDLDDPKDCFRWFKRNSNTGYLVAAAIALDWLAKSFIYDS

Function :

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity).