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P95855

UniProt ID :

P95855

NCBI Taxonomy :

273057

Protein names :

DNA protection during starvation protein

Organism :

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomy :

Archaea

Subcellular locations :

Cytoplasm;

Length :

188

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005737	Cellular Component	cytoplasm	IEA
GO:0009295	Cellular Component	nucleoid	IEA
GO:0008199	Molecullar Function	ferric iron binding	IEA
GO:0016491	Molecullar Function	oxidoreductase activity	IEA
GO:0006879	Biological Process	cellular iron ion homeostasis	IEA

Catalytic activity :

2 Fe(2+) + H₂O₂ + 2 H⁺ = 2 Fe³⁺ + 2 H₂O.

SWISS-MODEL Repository :

P95855

Sequences :

MQEKPQEPKVVGVEILEKSGLDIKKLVDKLVKATAAEFTTYYYYTILRMHLTGMEGEGLKEIAEDARLEDRLHFELMTQRIYELGGGLPRDIRQLADISACSDAYLPENWKDPKEILKVLLEAEQCAIRTWKEVCDMTYGKDPRTYDLAQRILQEEIEHEAWFLELLYGRPSGHFRRSSPGNAPYSKK

Function :

Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). In vitro, it efficiently oxidizes Fe(2+) in the presence of hydrogen peroxide and stores it as a mineral core.