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P66004

UniProt ID :

P66004

NCBI Taxonomy :

1773

Protein names :

Dihydrolipoyl dehydrogenase

Organism :

Mycobacterium tuberculosis

Taxonomy :

Bacteria

Subcellular locations :

Cytoplasm;

Length :

464

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IDA
GO:0005576	Cellular Component	extracellular region	IDA
GO:0005886	Cellular Component	plasma membrane	IDA
GO:0045254	Cellular Component	pyruvate dehydrogenase complex	IDA
GO:0016209	Molecullar Function	antioxidant activity	IEA
GO:0004148	Molecullar Function	dihydrolipoyl dehydrogenase activity	IDA
GO:0015036	Molecullar Function	disulfide oxidoreductase activity	IDA
GO:0050660	Molecullar Function	flavin adenine dinucleotide binding	IDA
GO:0070404	Molecullar Function	NADH binding	IDA
GO:0016655	Molecullar Function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA
GO:0045454	Biological Process	cell redox homeostasis	IDA
GO:0006096	Biological Process	glycolysis	IEA
GO:0040007	Biological Process	growth	IMP
GO:0009405	Biological Process	pathogenesis	IEA
GO:0052572	Biological Process	response to host immune response	TAS
GO:0006099	Biological Process	tricarboxylic acid cycle	IEA

Catalytic activity :

Protein N(6)-(dihydrolipoyl)lysine + NAD⁺ = protein N(6)-(lipoyl)lysine + NADH.Binds 1 FAD per subunit.

SWISS-MODEL Repository :

P66004

Sequences :

MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF

Function :

Lipoamide dehydrogenase is an essential component of the alpha-ketoacid dehydrogenase complexes, namely the pyruvate dehydrogenase (PDH) complex, the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, and likely also the 2-oxoglutarate dehydrogenase (ODH) complex. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Is also able to catalyze the transhydrogenation of NADH and thio-NAD(+) in the absence of D,L-lipoamide, and the NADH-dependent reduction of quinones in vitro.