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P65633

UniProt ID :

P65633

NCBI Taxonomy :

1773

Protein names :

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Organism :

Mycobacterium tuberculosis

Taxonomy :

Bacteria

Length :

553

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005618	Cellular Component	cell wall	IDA
GO:0005829	Cellular Component	cytosol	IDA
GO:0005886	Cellular Component	plasma membrane	IDA
GO:0045254	Cellular Component	pyruvate dehydrogenase complex	IDA
GO:0016209	Molecullar Function	antioxidant activity	IEA
GO:0004148	Molecullar Function	dihydrolipoyl dehydrogenase activity	IDA
GO:0004742	Molecullar Function	dihydrolipoyllysine-residue acetyltransferase activity	IEA
GO:0031405	Molecullar Function	lipoic acid binding	IDA
GO:0045454	Biological Process	cell redox homeostasis	IDA
GO:0006096	Biological Process	glycolysis	IEA
GO:0040007	Biological Process	growth	IMP
GO:0009405	Biological Process	pathogenesis	IDA
GO:0052572	Biological Process	response to host immune response	TAS

Catalytic activity :

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.Binds 2 lipoyl cofactors covalently.

SWISS-MODEL Repository :

P65633

Sequences :

MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL

Function :

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).