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P63345

UniProt ID :

P63345

NCBI Taxonomy :

1773

Protein names :

Proteasome-associated ATPase

Organism :

Mycobacterium tuberculosis

Taxonomy :

Bacteria

Length :

609

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005618	Cellular Component	cell wall	IDA
GO:0005886	Cellular Component	plasma membrane	IDA
GO:0022623	Cellular Component	proteasome-activating nucleotidase complex	IDA
GO:0005524	Molecullar Function	ATP binding	IEA
GO:0016887	Molecullar Function	ATPase activity	IDA
GO:0032182	Molecullar Function	small conjugating protein binding	IDA
GO:0071732	Biological Process	cellular response to nitric oxide	IMP
GO:0019941	Biological Process	modification-dependent protein catabolic process	IDA
GO:0009405	Biological Process	pathogenesis	IMP
GO:0010499	Biological Process	proteasomal ubiquitin-independent protein catabolic process	IDA
GO:0051260	Biological Process	protein homooligomerization	IPI
GO:0043335	Biological Process	protein unfolding	IDA
GO:0051409	Biological Process	response to nitrosative stress	IMP

SWISS-MODEL Repository :

P63345

Sequences :

MGESERSEAFGIPRDSPLSSGDAAELEQLRREAAVLREQLENAVGSHAPTRSARDIHQLEARIDSLAARNSKLMETLKEARQQLLALREEVDRLGQPPSGYGVLLATHDDDTVDVFTSGRKMRLTCSPNIDAASLKKGQTVRLNEALTVVEAGTFEAVGEISTLREILADGHRALVVGHADEERVVWLADPLIAEDLPDGLPEALNDDTRPRKLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYADIGGLSRQIEQIRDAVELPFLHKELYREYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAHEAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTEFLPVHADDLAEFDGDRSACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESNLGQYL

Function :

ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.