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P57790

UniProt ID :

P57790

NCBI Taxonomy :

10116

Protein names :

Kelch-like ECH-associated protein 1

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

624

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005913	Cellular Component	cell-cell adherens junction	IDA
GO:0031463	Cellular Component	Cul3-RING ubiquitin ligase complex	ISS
GO:0005737	Cellular Component	cytoplasm	IDA
GO:0005925	Cellular Component	focal adhesion	IDA
GO:0005634	Cellular Component	nucleus	IDA
GO:0019694	Biological Process	alkanesulfonate metabolic process	IEP
GO:0071407	Biological Process	cellular response to organic cyclic compound	IEP
GO:0042994	Biological Process	cytoplasmic sequestering of transcription factor	IMP
GO:0009812	Biological Process	flavonoid metabolic process	IEP
GO:0006108	Biological Process	malate metabolic process	IEP
GO:0010629	Biological Process	negative regulation of gene expression	IDA
GO:0010499	Biological Process	proteasomal ubiquitin-independent protein catabolic process	ISS
GO:0051259	Biological Process	protein oligomerization	IDA
GO:0016567	Biological Process	protein ubiquitination	ISS
GO:0006355	Biological Process	regulation of transcription, DNA-dependent	IEA
GO:0035902	Biological Process	response to immobilization stress	IEP
GO:0010038	Biological Process	response to metal ion	IEP
GO:0097066	Biological Process	response to thyroid hormone stimulus	IEP
GO:0001887	Biological Process	selenium compound metabolic process	IEP
GO:0006351	Biological Process	transcription, DNA-dependent	IEA

SWISS-MODEL Repository :

P57790

Sequences :

MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASLSVPRNRSGGGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC

Function :

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).