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P55157

UniProt ID :

P55157

NCBI Taxonomy :

9606

Protein names :

Microsomal triglyceride transfer protein large subunit

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Endoplasmic reticulum;

Length :

894

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0016323	Cellular Component	basolateral plasma membrane	IEA
GO:0031526	Cellular Component	brush border membrane	IEA
GO:0005788	Cellular Component	endoplasmic reticulum lumen	TAS
GO:0005794	Cellular Component	Golgi apparatus	IEA
GO:0031988	Cellular Component	membrane-bounded vesicle	IEA
GO:0031528	Cellular Component	microvillus membrane	IEA
GO:0005791	Cellular Component	rough endoplasmic reticulum	IEA
GO:0008289	Molecullar Function	lipid binding	IEA
GO:0005319	Molecullar Function	lipid transporter activity	TAS
GO:0042632	Biological Process	cholesterol homeostasis	IEA
GO:0006629	Biological Process	lipid metabolic process	TAS
GO:0042157	Biological Process	lipoprotein metabolic process	TAS
GO:0042953	Biological Process	lipoprotein transport	IEA
GO:0006497	Biological Process	protein lipidation	IEA
GO:0051592	Biological Process	response to calcium ion	IEA
GO:0044281	Biological Process	small molecule metabolic process	TAS
GO:0006641	Biological Process	triglyceride metabolic process	IEA

Sequences :

MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

Function :

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.