show

P53615

UniProt ID :

P53615

NCBI Taxonomy :

559292

Protein names :

Carbonic anhydrase

Organism :

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;Mitochondrion intermembrane space;

Length :

221

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005758	Cellular Component	mitochondrial intermembrane space	IDA
GO:0005634	Cellular Component	nucleus	IEA
GO:0004089	Molecullar Function	carbonate dehydratase activity	IDA
GO:0008270	Molecullar Function	zinc ion binding	IEA
GO:0015976	Biological Process	carbon utilization	IEA
GO:0071244	Biological Process	cellular response to carbon dioxide	IMP
GO:0034599	Biological Process	cellular response to oxidative stress	IMP

Catalytic activity :

H₂CO(3) = CO₂ + H₂O.Binds 1 zinc ion per subunit (By similarity).

SWISS-MODEL Repository :

P53615

Sequences :

MSATESSSIFTLSHNSNLQDILAANAKWASQMNNIQPTLFPDHNAKGQSPHTLFIGCSDSRYNENCLGVLPGEVFTWKNVANICHSEDLTLKATLEFAIICLKVNKVIICGHTDCGGIKTCLTNQREALPKVNCSHLYKYLDDIDTMYHEESQNLIHLKTQREKSHYLSHCNVKRQFNRIIENPTVQTAVQNGELQVYGLLYNVEDGLLQTVSTYTKVTPK

Function :

Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence.