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P48506

UniProt ID :

P48506

NCBI Taxonomy :

9606

Protein names :

Glutamate--cysteine ligase catalytic subunit

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Length :

637

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	TAS
GO:0017109	Cellular Component	glutamate-cysteine ligase complex	IEA
GO:0043531	Molecullar Function	ADP binding	IDA
GO:0005524	Molecullar Function	ATP binding	IEA
GO:0050662	Molecullar Function	coenzyme binding	IPI
GO:0016595	Molecullar Function	glutamate binding	IDA
GO:0004357	Molecullar Function	glutamate-cysteine ligase activity	IDA
GO:0000287	Molecullar Function	magnesium ion binding	IDA
GO:0045454	Biological Process	cell redox homeostasis	IDA
GO:0006534	Biological Process	cysteine metabolic process	IDA
GO:0006536	Biological Process	glutamate metabolic process	IDA
GO:0006750	Biological Process	glutathione biosynthetic process	IDA
GO:1901687	Biological Process	glutathione derivative biosynthetic process	TAS
GO:0019852	Biological Process	L-ascorbic acid metabolic process	IEA
GO:0043066	Biological Process	negative regulation of apoptotic process	IDA
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IEA
GO:0031397	Biological Process	negative regulation of protein ubiquitination	IEA
GO:0045892	Biological Process	negative regulation of transcription, DNA-dependent	IDA
GO:0032436	Biological Process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0050880	Biological Process	regulation of blood vessel size	IMP
GO:0051900	Biological Process	regulation of mitochondrial depolarization	IEA
GO:0046685	Biological Process	response to arsenic-containing substance	IEA
GO:0009408	Biological Process	response to heat	IDA
GO:0009725	Biological Process	response to hormone stimulus	IDA
GO:0051409	Biological Process	response to nitrosative stress	IEA
GO:0006979	Biological Process	response to oxidative stress	IDA
GO:0006805	Biological Process	xenobiotic metabolic process	TAS

Catalytic activity :

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

SWISS-MODEL Repository :

P48506

Sequences :

MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN