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P46418

UniProt ID :

P46418

NCBI Taxonomy :

10116

Protein names :

Glutathione S-transferase alpha-5

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;

Length :

221

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IDA
GO:0005640	Cellular Component	nuclear outer membrane	IDA
GO:0008144	Molecullar Function	drug binding	IDA
GO:0043295	Molecullar Function	glutathione binding	IDA
GO:0004364	Molecullar Function	glutathione transferase activity	IDA
GO:0007568	Biological Process	aging	IEP
GO:0042493	Biological Process	response to drug	NAS
GO:0031667	Biological Process	response to nutrient levels	IEP
GO:0042178	Biological Process	xenobiotic catabolic process	IDA

Catalytic activity :

RX + glutathione = HX + R-S-glutathione.

SWISS-MODEL Repository :

P46418

Sequences :

MPGKPVLHYFDGRGRMEPIRWLLAAAGVEFEENFLKTRDDLARLRSDGSLMFEQVPMVEIDGMKLVQTKAILNYIATKYNLYGKDMKERALIDMYAEGVADLELMVLYYPYMPPGEKEASLAKIKDKARNRYFPAYEKVLKSHGQDYLVGNKLSRADVSLVELLYHVEEMDPGIVDNFPLLKALRTRVSNLPTVKKFLQPGSQRKPFDDEKCVESAKKIFS

Function :

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide.