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P46309

UniProt ID :

P46309

NCBI Taxonomy :

3702

Protein names :

Glutamate--cysteine ligase, chloroplastic

Organism :

Arabidopsis thaliana

Taxonomy :

Eukaryota

Subcellular locations :

Plastid;

Length :

522

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0009570	Cellular Component	chloroplast stroma	IDA
GO:0005524	Molecullar Function	ATP binding	IEA
GO:0004357	Molecullar Function	glutamate-cysteine ligase activity	IDA
GO:0052544	Biological Process	defense response by callose deposition in cell wall	IMP
GO:0009816	Biological Process	defense response to bacterium, incompatible interaction	IMP
GO:0050832	Biological Process	defense response to fungus	IMP
GO:0002213	Biological Process	defense response to insect	IMP
GO:0009908	Biological Process	flower development	IMP
GO:0019761	Biological Process	glucosinolate biosynthetic process	IMP
GO:0006750	Biological Process	glutathione biosynthetic process	IDA
GO:0009700	Biological Process	indole phytoalexin biosynthetic process	IMP
GO:0046686	Biological Process	response to cadmium ion	IMP
GO:0009408	Biological Process	response to heat	IMP
GO:0009753	Biological Process	response to jasmonic acid stimulus	IEP
GO:0010193	Biological Process	response to ozone	IEP

Catalytic activity :

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

SWISS-MODEL Repository :

P46309

Sequences :

MALLSQAGGSYTVVPSGVCSKAGTKAVVSGGVRNLDVLRMKEAFGSSYSRSLSTKSMLLHSVKRSKRGHQLIVAASPPTEEAVVATEPLTREDLIAYLASGCKTKDKYRIGTEHEKFGFEVNTLRPMKYDQIAELLNGIAERFEWEKVMEGDKIIGLKQGKQSISLEPGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEEMGIGFLGIGFQPKWRREDIPIMPKGRYDIMRNYMPKVGTLGLDMMLRTCTVQVNLDFSSEADMIRKFRAGLALQPIATALFANSPFTEGKPNGFLSMRSHIWTDTDKDRTGMLPFVFDDSFGFEQYVDYALDVPMYFAYRKNKYIDCTGMTFRQFLAGKLPCLPGELPSYNDWENHLTTIFPEVRLKRYLEMRGADGGPWRRLCALPAFWVGLLYDDDSLQAILDLTADWTPAEREMLRNKVPVTGLKTPFRDGLLKHVAEDVLKLAKDGLERRGYKEAGFLNAVDEVVRTGVTPAEKLLEMYNGEWGQSVDPVFEELLY

Function :

Seems to play an important role in controlling the expression of resistance responses like the regulation of salicylic acid (SA) and phytoalexin (camalexin) production. Involved in resistance to fungal and bacterial pathogens. Required for the regulation of cell proliferation in root apical meristems through the GSH-dependent developmental pathway. Also participates to the detoxification process, the antioxidant response and is essential for embryo development and proper seed maturation.