show

P41975

UniProt ID :

P41975

NCBI Taxonomy :

9986

Protein names :

Extracellular superoxide dismutase [Cu-Zn]

Organism :

Oryctolagus cuniculus

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

244

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0031012	Cellular Component	extracellular matrix	IEA
GO:0005615	Cellular Component	extracellular space	IEA
GO:0005802	Cellular Component	trans-Golgi network	IEA
GO:0005507	Molecullar Function	copper ion binding	IEA
GO:0004784	Molecullar Function	superoxide dismutase activity	IEA
GO:0008270	Molecullar Function	zinc ion binding	IEA
GO:0001666	Biological Process	response to hypoxia	IEA
GO:0006801	Biological Process	superoxide metabolic process	IEA

Catalytic activity :

2 superoxide + 2 H⁺ = O₂ + H₂O₂.

Sequences :

MLALVCSCLLLAALPADTWSGPAAVELGSDTVEQIRDTHAKVTEIWQALTQQRAAQGEPAGALHAVCRVQPSATLDAAQPRVSGLVVFRQLGPGAQLEAFFDLEGFPVEANLSSRAIHVHQFGDLSQGCDSTGAHYNPLAVQHPQHPGDFGNFAVRDGRLWKYRSGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNAASVENGNAGPRLACCVVGASGPAPWARQAQEHAERKKRRRESECKAA

Function :

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen (By similarity).