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P40553

UniProt ID :

P40553

NCBI Taxonomy :

559292

Protein names :

Peroxiredoxin DOT5

Organism :

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Taxonomy :

Eukaryota

Subcellular locations :

Nucleus;Chromosome;

Length :

215

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0000781	Cellular Component	chromosome, telomeric region	IEA
GO:0005634	Cellular Component	nucleus	IDA
GO:0008379	Molecullar Function	thioredoxin peroxidase activity	IDA
GO:0045454	Biological Process	cell redox homeostasis	IDA
GO:0034599	Biological Process	cellular response to oxidative stress	IGI
GO:0006355	Biological Process	regulation of transcription, DNA-dependent	IEA
GO:0006351	Biological Process	transcription, DNA-dependent	IEA

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

P40553

Sequences :

MGEALRRSTRIAISKRMLEEEESKLAPISTPEVPKKKIKTGPKHNANQAVVQEANRSSDVNELEIGDPIPDLSLLNEDNDSISLKKITENNRVVVFFVYPRASTPGCTRQACGFRDNYQELKKYAAVFGLSADSVTSQKKFQSKQNLPYHLLSDPKREFIGLLGAKKTPLSGSIRSHFIFVDGKLKFKRVKISPEVSVNDAKKEVLEVAEKFKEE

Function :

Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival.