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P32119

UniProt ID :

P32119

NCBI Taxonomy :

9606

Protein names :

Peroxiredoxin-2

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;

Length :

198

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005737	Cellular Component	cytoplasm	TAS
GO:0005829	Cellular Component	cytosol	IEA
GO:0008379	Molecullar Function	thioredoxin peroxidase activity	IDA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	TAS
GO:0043066	Biological Process	negative regulation of apoptotic process	TAS
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IEA
GO:0019430	Biological Process	removal of superoxide radicals	IDA

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

P32119

Sequences :

MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Function :

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).