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P30048

UniProt ID :

P30048

NCBI Taxonomy :

9606

Protein names :

Thioredoxin-dependent peroxide reductase, mitochondrial

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Mitochondrion;

Length :

256

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005769	Cellular Component	early endosome	IDA
GO:0005739	Cellular Component	mitochondrion	IDA
GO:0008785	Molecullar Function	alkyl hydroperoxide reductase activity	NAS
GO:0043027	Molecullar Function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP
GO:0004601	Molecullar Function	peroxidase activity	IEA
GO:0051920	Molecullar Function	peroxiredoxin activity	IEA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	IMP
GO:0001893	Biological Process	maternal placenta development	IEA
GO:0007005	Biological Process	mitochondrion organization	IMP
GO:0030099	Biological Process	myeloid cell differentiation	ISS
GO:0043066	Biological Process	negative regulation of apoptotic process	IMP
GO:0033673	Biological Process	negative regulation of kinase activity	IDA
GO:0008284	Biological Process	positive regulation of cell proliferation	IDA
GO:0051092	Biological Process	positive regulation of NF-kappaB transcription factor activity	IDA
GO:0051881	Biological Process	regulation of mitochondrial membrane potential	IMP
GO:0032496	Biological Process	response to lipopolysaccharide	ISS

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

SWISS-MODEL Repository :

P30048

Sequences :

MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ

Function :

Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.