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P30041

UniProt ID :

P30041

NCBI Taxonomy :

9606

Protein names :

Peroxiredoxin-6

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Lysosome;Cytoplasmic vesicle;

Length :

224

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0016023	Cellular Component	cytoplasmic membrane-bounded vesicle	IEA
GO:0005829	Cellular Component	cytosol	NAS
GO:0005764	Cellular Component	lysosome	IEA
GO:0016209	Molecullar Function	antioxidant activity	NAS
GO:0004602	Molecullar Function	glutathione peroxidase activity	IEA
GO:0051920	Molecullar Function	peroxiredoxin activity	IEA
GO:0004623	Molecullar Function	phospholipase A2 activity	IDA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	IEA
GO:0009395	Biological Process	phospholipid catabolic process	IDA
GO:0006979	Biological Process	response to oxidative stress	IDA

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.

SWISS-MODEL Repository :

P30041

Sequences :

MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

Function :

Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.