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P27170

UniProt ID :

P27170

NCBI Taxonomy :

9986

Protein names :

Serum paraoxonase/arylesterase 1

Organism :

Oryctolagus cuniculus

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

359

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	NAS
GO:0034364	Cellular Component	high-density lipoprotein particle	IEA
GO:0016209	Molecullar Function	antioxidant activity	IDA
GO:0004063	Molecullar Function	aryldialkylphosphatase activity	ISS
GO:0004064	Molecullar Function	arylesterase activity	IDA
GO:0005509	Molecullar Function	calcium ion binding	ISS
GO:0046683	Biological Process	response to organophosphorus	IDA

Catalytic activity :

A phenyl acetate + H₂O = a phenol + acetate.An aryl dialkyl phosphate + H₂O = dialkyl phosphate + an aryl alcohol.An N-acyl-L-homoserine lactone + H₂O = an N-acyl-L-homoserine.

SWISS-MODEL Repository :

P27170

Sequences :

MAKLTALTLLGLGLALFDGQKSSFQTRFNVHREVTPVELPNCNLVKGIDNGSEDLEILPNGLAFISAGLKYPGIMSFDPDKPGKILLMDLNEKDPVVLELSITGSTFDLSSFNPHGISTFTDEDNIVYLMVVNHPDSKSTVELFKFQEKEKSLLHLKTIRHKLLPSVNDIVAVGPEHFYATNDHYFIDPYLKSWEMHLGLAWSFVTYYSPNDVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPVTGDLWVGCHPNGMRIFYYDPKNPPASEVLRIQDILSKEPKVTVAYAENGTVLQGSTVAAVYKGKMLVGTVFHKALYCELSQAN

Function :

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.