show

P20735

UniProt ID :

P20735

NCBI Taxonomy :

9823

Protein names :

Gamma-glutamyltranspeptidase 1

Organism :

Sus scrofa

Taxonomy :

Eukaryota

Subcellular locations :

Membrane;

Length :

568

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0016021	Cellular Component	integral to membrane	IEA
GO:0003840	Molecullar Function	gamma-glutamyltransferase activity	ISS
GO:0036374	Molecullar Function	glutathione hydrolase activity	IEA
GO:0006750	Biological Process	glutathione biosynthetic process	IEA

Catalytic activity :

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.Glutathione + H₂O = L-cysteinylglycine + L-glutamate.Leukotriene C(4) + H₂O = leukotriene D(4) + L-glutamate.

Sequences :

MKKRYLLLALAAVALVLLILGLCLWLPSNSKPHNHVYPRAAVAADALRCSEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEIINAREVAPRLASASMFNSSEQSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIELASQGFPVGKGLAAALERSQDAIKRHPALCEVFCRNGNVLREGDLVTMPRLAKTYETLAVEGAQAFYNGSLTAQIVKDIQEAGGIVTAEDLNNYRAELIEQPLRISLGDAQLYAPNAPLSGPVLALILNILKGYNFSRASVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVNVTEVVRNMSSEFFADQLRARISDTTTHPDSYYEPEFYTPDDAGTAHLSVVSDDGSAVSATSTINLYFGSKVRSRISGILFNDEMDDFSSPNITNQFGVRPSPANFITPGKQPLSSMCPVIIVGEDGQVRMVVGASGGTQITTSTALAIIHSLWFGYDVKRAVEEPRLHNQLLPNTTTLEKGIDQAVAAALKTRHHYIQDASTFIGVVQAIVRTPSGWAAASDSRKGGEPAGY

Function :

Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate.