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P19440

UniProt ID :

P19440

NCBI Taxonomy :

9606

Protein names :

Gamma-glutamyltranspeptidase 1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Membrane;

Length :

569

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0031362	Cellular Component	anchored to external side of plasma membrane	TAS
GO:0016021	Cellular Component	integral to membrane	IEA
GO:0003840	Molecullar Function	gamma-glutamyltransferase activity	IDA
GO:0036374	Molecullar Function	glutathione hydrolase activity	IEA
GO:0019369	Biological Process	arachidonic acid metabolic process	TAS
GO:0019344	Biological Process	cysteine biosynthetic process	ISS
GO:0006750	Biological Process	glutathione biosynthetic process	ISS
GO:1901687	Biological Process	glutathione derivative biosynthetic process	TAS
GO:0019370	Biological Process	leukotriene biosynthetic process	IMP
GO:0002682	Biological Process	regulation of immune system process	ISS
GO:0050727	Biological Process	regulation of inflammatory response	ISS
GO:0007283	Biological Process	spermatogenesis	ISS
GO:0006805	Biological Process	xenobiotic metabolic process	TAS

Catalytic activity :

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.Glutathione + H₂O = L-cysteinylglycine + L-glutamate.Leukotriene C(4) + H₂O = leukotriene D(4) + L-glutamate.

SWISS-MODEL Repository :

P19440

Sequences :

MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY

Function :

Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.