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P19007

UniProt ID :

P19007

NCBI Taxonomy :

9986

Protein names :

Haptoglobin

Organism :

Oryctolagus cuniculus

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

347

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	IEA
GO:0016209	Molecullar Function	antioxidant activity	IEA
GO:0003824	Molecullar Function	catalytic activity	IEA
GO:0006953	Biological Process	acute-phase response	IEA
GO:0042742	Biological Process	defense response to bacterium	IEA
GO:0008152	Biological Process	metabolic process	IEA

Sequences :

MRALGAVITLLLWGQLFAADFGNEVTDIADDSCPKPPEIANGYVEHLVRYQCKNYYRLRTEGDGVYALNSEKQWVNKAVGEQLPECEAVCGKPKHPVDQVQRIIGGSLDAKGSFPWQAKMVSRHNLVTGATLISEQWLLTTAKNLFLNHTENATAQDIAPTLTLYLGRRQLVEIEKVVLHPNYSEVDIGLIKLKDKVPVNERVMPICLPSKDYTEVGRVGYVSGWGRNSNFTYTDHLKYVMLPVADQDKCIQHYENSTVPENKIPKNPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSTFAIHDLQQDTWYAAGILSFDKSCTVAEYGVYVKTFNILDWIQKTIASN

Function :

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).