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P18846

UniProt ID :

P18846

NCBI Taxonomy :

9606

Protein names :

Cyclic AMP-dependent transcription factor ATF-1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Nucleus;

Length :

271

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005654	Cellular Component	nucleoplasm	TAS
GO:0005667	Cellular Component	transcription factor complex	IEA
GO:0043565	Molecullar Function	sequence-specific DNA binding	IEA
GO:0003700	Molecullar Function	sequence-specific DNA binding transcription factor activity	TAS
GO:0045087	Biological Process	innate immune response	TAS
GO:0002755	Biological Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0048011	Biological Process	neurotrophin TRK receptor signaling pathway	TAS
GO:0051403	Biological Process	stress-activated MAPK cascade	TAS
GO:0034166	Biological Process	toll-like receptor 10 signaling pathway	TAS
GO:0034134	Biological Process	toll-like receptor 2 signaling pathway	TAS
GO:0034138	Biological Process	toll-like receptor 3 signaling pathway	TAS
GO:0034142	Biological Process	toll-like receptor 4 signaling pathway	TAS
GO:0034146	Biological Process	toll-like receptor 5 signaling pathway	TAS
GO:0034162	Biological Process	toll-like receptor 9 signaling pathway	TAS
GO:0038123	Biological Process	toll-like receptor TLR1:TLR2 signaling pathway	TAS
GO:0038124	Biological Process	toll-like receptor TLR6:TLR2 signaling pathway	TAS
GO:0006351	Biological Process	transcription, DNA-dependent	IEA
GO:0035666	Biological Process	TRIF-dependent toll-like receptor signaling pathway	TAS

SWISS-MODEL Repository :

P18846

Sequences :

MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV

Function :

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.