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P13635

UniProt ID :

P13635

NCBI Taxonomy :

10116

Protein names :

Ceruloplasmin

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

1059

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0046658	Cellular Component	anchored to plasma membrane	IDA
GO:0005615	Cellular Component	extracellular space	IDA
GO:0005507	Molecullar Function	copper ion binding	IDA
GO:0004322	Molecullar Function	ferroxidase activity	TAS
GO:0007568	Biological Process	aging	IEP
GO:0006879	Biological Process	cellular iron ion homeostasis	TAS
GO:0001889	Biological Process	liver development	IEP
GO:0030324	Biological Process	lung development	IEP
GO:0015679	Biological Process	plasma membrane copper ion transport	TAS
GO:0046688	Biological Process	response to copper ion	IDA
GO:0007584	Biological Process	response to nutrient	IEP

Catalytic activity :

4 Fe(2+) + 4 H⁺ + O₂ = 4 Fe³⁺ + 2 H₂O.Binds 6 copper ions per monomer.

Sequences :

MKFLLLSALLFLHSSLAWTREKHYYIGITEAVWDYASGSEEKELISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGFLGPVIKAEVGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLRANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEENIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPDDDIQDRHVRHYYIAAEETIWDYAPSGTDTFTGENFTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKERGPDEEHLGILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGRSSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNGFMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVEWDYSPSRDWEMELHHLQEQNVSNAFLDKEEFFIGSKYKKVVYREFTDSTFREQVKRRAEEEHLGMLGPLIHADVGAKVKVVFKNMATRPYSIHAHGVKTKSSTVAPTLPGEVRTYIWQIPERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEFSLLFLVFDENESWYLDDNINTYPDHPEKDNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMAMGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDFFPGTYQTLEMFPQTPGTWLLHCHVTDHIHAGMVTTYTVLPNQETKSG

Function :

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1.