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P0CB50

UniProt ID :

P0CB50

NCBI Taxonomy :

9031

Protein names :

Peroxiredoxin-1

Organism :

Gallus gallus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;

Length :

199

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005739	Cellular Component	mitochondrion	IEA
GO:0005634	Cellular Component	nucleus	IEA
GO:0008379	Molecullar Function	thioredoxin peroxidase activity	IEA
GO:0042744	Biological Process	hydrogen peroxide catabolic process	IEA

Catalytic activity :

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.

Sequences :

MSSGKAFIGKPAPDFTATAVMPDGQFKDIKLSDYRGKYVVFFFYPLDFTFVCPTEIIAYSDRADEFKKINCEIIGASVDSHFCHLAWINTPKKQGGLGTMKIPLVSDTKRVIAKDYGVLKEDEGIAYRGLFIIDEKGILRQITINDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK

Function :

Involved in redox regulation of the cell (By similarity). Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin (By similarity). May play an important role in eliminating peroxides generated during metabolism (By similarity). Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.